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Optical Separation of Racemic Phenyl-alanine,and Structure of Complex Consisting of R-Phenylalanine and R-Mandelic Acid
The racemic phenylalanine has been separated by (R)-mandelic acid through the formation of diastereomeric molecular complex. The crystal of the title chiral complex (C8H8O3·C9H11NO2, Mr = 317.33) belongs to monoclinic, space group C2 with a = 19.391(3), b = 5.715(4), c = 15.755(3)A,β= 115.23(1)°, V = 1579(1) A3, Z = 4, Dc = 1.335 g/cm3, F(000) = 672, μ= 0.099 mm-1, R = 0.033 and Wr = 0.060 for 1278 observed reflections (I > 2σ(I)). The complex consists of (R)-mandelic acid and (R)-phenylalanine in 1:1 molar ratio, and the complex molecules form layered crystal structure by self-assembly through intermolecular H-bonding between carboxyl and carboxylate of the neighboring molecules.
作 者： 胡自强 徐端钧 徐元植 吴景云 蒋燕南 作者单位： 胡自强,徐端钧,徐元植(Department of Chemistry,Zhejiang University,Hangzhou 310027,China)吴景云,蒋燕南(Department of Chemistry,National Sun Yat-Sen University,Kaohsiung,China)
刊 名： 结构化学 ISTIC SCI PKU 英文刊名： CHINESE JOURNAL OF STRUCTURAL CHEMISTRY 年，卷(期)： 2004 23(1) 分类号： O641 关键词： optical separation crystal structure mandelic acid phenylalanine