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Synthesis of Dithiocarbamate Derivatives of Quinazolinone and Their in vitro Antitumor Activity
Because of the essential role of thymidylate synthase (TS) in DNA biosynthesis, [1] many TS inhibitors have been designed for the treatment of cancer, [2] of which Raltitrexed has been successfully used for the first-line treat ment of advanced colorectal cancer. [3]Acknowledgements We thank National Center for pharmaceutical screening, Institute of Materia Medica, Chi-nese Academy of Medical Sciences, for in vitro antitumor activity screening.
作 者： CAO Sheng-li FENG Yu-ping WAN Rong LI Run-Tao 作者单位： CAO Sheng-li(Department of Chemistry, Capital Normal University, Beijing 100037)FENG Yu-ping,WAN Rong(Department of Chemistry, Tsinghua University, Beijing 100084)
LI Run-Tao(School of Pharmaceutical Sciences, Peking University, Bering 100083)
刊 名： 有机化学 ISTIC SCI PKU 英文刊名： CHINESE JOURNAL OF ORGANIC CHEMISTRY 年，卷(期)： 2003 23(z1) 分类号： O6 关键词：【Synthesis of Dithiocarbamate Derivat】相关文章：
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